CALL FOR PAPERS Autophagy in the Cardiovascular System MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy
نویسندگان
چکیده
Kenshi Higashi, Yoshihisa Yamada, Shingo Minatoguchi, Shinya Baba, Masamitsu Iwasa, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Genzou Takemura, Minami Kumazaki, Yukihiro Akao, and Shinya Minatoguchi Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan; and United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University Gifu, Japan
منابع مشابه
MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy.
We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in a rabbit model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 min of coronary occlusion, followed by 2 days or 2 wk of reperfusion. Control microRNA (control group; 2.5 nmol/kg, n = 10) or miR-145 (miR-145 group, 2.5 nmol/kg, n = 10) encapsulated in liposomes was intravenously ad...
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